29 November, 2020

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Nexgard For Dogs Side Effects & Reviews

Nexgard for Dogs Side Effects & Reviews

Nexgard for Dogs Side Effects & Reviews

Having furry friends at home can be a mess when there are disgusting ticks and fleas latched on their thick coat. Unlike short-fur breeds, your Pomeranian and Shih Tzu are more prone to tick infestations. Although there are natural methods to get rid of fleas, pet owners sometimes choose a quick fix to end this pestilence.

One of the most common flea control products on the market today is Nexgard. It’s important to understand how to properly use this product to avoid side effects. But how does this tick control product work, and is it really effective?

What Is Nexgard for Dogs?

Nexgard for dogs is a bite-sized chewable tablet in beef flavor. It is formulated to kill fleas and prevent them from laying eggs, which often leads to infestation. With its fast-acting formula, dogs that are 8 weeks old and above, and weigh more than 4 pounds should be given a monthly dosage to get protection all year round.

The advanced formulation is created by Frontline Plus makers, one of the leading names in pet health that veterinarians trust. As a parasitic treatment that is given to dogs once a month, Nexgard has become a popular name when it comes to killing ticks and fleas, and preventing infestations in dogs and cats.

Since the 70s, billions of Frontline products were used to treat pets with fleas across the globe. In 2013, the Food and Drug Administration approved Nexgard for use, and it quickly became the go-to treatment for pet owners. Almost all vets everywhere strongly recommend this pet medication for tick infestation as it gives good results with monthly use.

Dosage of Nexgard

The orange box is formulated for dogs weighing 4-10 pounds. It contains 11.3 milligrams of Afoxolaner, administered orally once every month. The blue box is for dogs 10.1-24 pounds and contains 28.3 milligrams of Afoxolaner, administered orally once every month.

The purple box is for dogs that are 24.1-60 pounds and contains 68 milligrams of Afoxolaner, administered orally once every month. The red box is for dogs 60.1-121 pounds and contains 136 milligrams of Afoxolaner, administered orally once every month.

Side Effects of Nexgard

Some of the mild side effects of administering Nexgard to pets include dry skin, loss of appetite, diarrhea, and vomiting. However, if these symptoms worsen, make sure to consult your local vet for proper treatment. Serious side effects or those that indicate severe problems are: 

  • nonstop vomiting
  • difficulty walking
  • seizures
  • tremors
  • decreased appetite
  • stumbling
  • weakness

Immediately seek professional help if you notice your dog exhibiting these signs. The most common adverse reaction you may observe in your dog is vomiting. However, the symptom is generally self-limiting while it slowly disappears after subsequent doses given to pets.

Cost of Nexgard

Like other pet products, prices of Nexgard vary depending on the availability, dosage, and location. The average cost for this flea control product is around $72 for 3 months, $112 for 6 months, and $200 for 12 months. These are only estimated costs as list prices from each shop may be cheaper or more expensive than others.

Moreover, this prescription-only vet drug may not be obtained online or at any random shop for pet-related items. It’s highly advised to talk to your veterinarian before purchasing Nexgard for your dog.

Interaction with Other Drugs

When it comes to food and other drug interactions, there are no proven contraindications for administering Nexgard to dogs or other pets. In fact, a field study did not record any adverse reactions after using Nexgard with antibiotics, antihistamines, anesthetics, NSAIDs, steroids, anthelmintics, and vaccines.

Furthermore, dogs that were sham-dosed in a study showed no signs of any negative effects while they were given treatments in clinical pathology, food consumption, body weight, and physical examination. The only adverse effect was vomiting in the controlled group, particularly dogs that vomited after 4 hours of treatment.

There are some precautions to consider before you administer Nexgard to your dogs monthly. The use of this tick control product in lactating, pregnant, or breeding dogs hasn’t been evaluated for safety reasons. For instance, if your dog has seizures and other related health conditions, Nexgard must be used with extra caution.

Ingredients in Nexgard

The active ingredient used in formulating Nexgard is Afoxolaner. According to studies, this is a highly effective ingredient that offers no side effects or adverse reactions to dogs. Therefore, it’s a safe substance to administer in pets that have fleas and ticks on their thick fur.

Afoxolaner is an isoxazoline substance that is attracted by a binding tract to suppress louse and “acarine ligand-gated chloride” passages such as those blocked by neurotransmitter GABA (gamma-aminobutyric acid). Therefore, the pre-synaptic and post-synaptic movement of chloride particles through the cell membranes is also blocked.

If hyperexcitation of Afoxolaner-induced compounds is prolonged, then the result can be uncontrolled activity in the nervous system while killing acarine and insects. The exclusive toxicity of this active ingredient between acarine and insects, as well as mammals, is deduced by the derivative sensitivity of GABA receptors in acarine and insects against the GABA receptors of mammals.


Depending on body weight, Nexgard should be given to dogs with the proper dosage to avoid side effects and other serious problems. Improper use may counteract the effectiveness of this active ingredient and may lead to some mild symptoms. An ingredient used in making drugs for diarrhea can also induce certain side effects in some dogs.


There is plenty of antiparasitic products available on the market today. Nexgard is just one of the many options you can try for your pet’s needs. Always check the label before buying any pet products, particularly the FDA approval.